Andreas mayer max planck biography

Research Interests

1. Membrane fission on endo-lysosomal compartments

Endo-lysosomal compartments control the abundance of most plasma membrane transporters and receptors, and thereby determine the communication, interaction and transport capacities of cells.

Andreas mayer max planck biography

Endosomes receive proteins from the cell surface or from the Golgi and recycle them either back to these compartments, or transfer them to lysosomes, where many of them become degraded. Endo-lysosomal compartments vigorously exchange material through homo- and heterotypic fusion and fission, and through tubulo-vesicular carriers.

Carriers grow by polymerisation of proteinaceous coats, such as retromer, which collect cargo proteins and then detach from the organelle by membrane fission.

Persistence of the endo-lysosomal network depends on the control of the formation and fission of such carriers and on their coordination with the availability of membrane and/or cargo.

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